Abstract:Tolerogenic dendritic cells (tolDCs) are critical for regulation of immune tolerance in organ transplantation and autoimmune diseases. Compared with immunosuppressants, the side effects of tolDCs for treatment after transplantation are fewer. In addition, tolDCs can be cultivated by a variety of ways and different culture methods have different efficacies. At present, tolDCs have been widely used in clinical trials as an adjuvant therapy to induce organ transplant tolerance. Herein, the immune tolerance induced by tolDCs, culture methods of tolDCs in vitro, miRNAs regulatory mechanism and application of tolDCs were reviewed, and related research prospects were put forward, with the hope of providing guidance for tolDCs therapy to reduce transplantation rejection.
引用本文:
孙庐云, 丁 喆, 陈 鹏, 刘 锋, 宝福凯, 胡明道. 耐受性树突状细胞的研究进展[J]. 生命科学研究, 2020, 24(4): 314-320.
SUN Lu-yun, DING Zhe, CHEN Peng, LIU Feng, BAO Fu-kai, HU Ming-dao. Research Progress on Tolerogenic Dendritic Cells. Life Science Research, 2020, 24(4): 314-320.