Abstract:Abstract: Lyme disease is an infectious disease caused by Borrelia burgdorferi and mainly characterized by neurological diseases, skin lesions and joint damage after infection. Inflammation is an important factor in the occurrence and development of the disease once the human body is infected. CD14/TLR1-TLR2/p38 MAPK signaling pathway recognizes the surface lipoproteins of B. burgdorferi via CD14. Meanwhile, downstream signals, such as TLR1-TLR2, as well as p38 MAPK, are activated, and pro-inflammatory factors are secreted, resulting in the inflammation responses. The research progress of the inflammatory response induced by the CD14/TLR1-TLR2/p38 MAPK signaling pathway in the pathogenesis of Lyme disease is herein summarized.
引用本文:
陆丽红, 丁 喆, 简苗苗, 计震华, 宝福凯, 柳爱华. CD14/TLR1-TLR2/p38 MAPK信号通路在莱姆病发病机制中的作用[J]. 生命科学研究, 2020, 24(1): 81-86.
LU Li-hong, DING Zhe, JIAN Miao-miao, JI Zhen-hua, BAO Fu-kai, LIU Ai-hua. The Roles of CD14/TLR1-TLR2/p38 MAPK Signaling Pathway in Pathogenesis of Lyme Disease. Life Science Research, 2020, 24(1): 81-86.