Abstract:Abstract: DDB1- and CUL4-associated factors (DCAFs) are newly discovered family proteins which contain the “WDXR” domain. The DCAF proteins can form an E3 ubiquitin ligase with CRL4 and DDB1, and regulate a series of life activities such as cell growth, differentiation and apoptosis by ubiquitinating the target proteins. Abnormal expression of DCAF proteins is usually related to diseases such as tumors and developmental disorders. Herein the functions and the mechanisms of DCAF family proteins are discussed.
引用本文:
童柏陆, 刘晓倩, 汪 洌. DCAF家族蛋白研究进展[J]. 生命科学研究, 2020, 24(1): 75-80.
TONG Bo-lu, LIU Xiao-qian, WANG Lie. Advances in Functions of DCAF Family Proteins. Life Science Research, 2020, 24(1): 75-80.