Abstract:Abstract: As the smallest unit of living organisms, cells participate in a wide variety of biological activities. The biochemical reactions on the level of cells or even single molecules have been the focus of revealing the physiological activities of living organisms for quite a long time. In recent years, many studies have been carried out to illustrate the influences of matrix properties on cellular bioactivities. Cells are prone to be affected by mechanical microenvironment in many aspects, such as their viscoelasticity, the distribution and dynamics of proteins, the interaction among proteins, signaling pathways, et al. Meanwhile, cells can also respond to the environment and actively exert forces, resulting in the remodeling of the extracellular matrix, the process of which is called “mechanobiology”. As a consequence, it is significant to understand cell-matrix interactions in depth because it provides a new viewpoint to study the dynamics of physiological and pathological conditions as well as to design and develop advanced bionic scaffolds. Researches on the interactions between cells and matrix were summarized, and how matrix properties (e.g. rigidity and ligand density) influence cell behaviors (adhesion, migration and differentiation) was also discussed. These studies would provide the basics for future mechanobiological development.
引用本文:
李 倩,朱晓嫚,王纪浩,谢岩黎. 基质微环境力学与细胞生物学行为[J]. 生命科学研究, 2019, 23(6): 487-493.
LI Qian, ZHU Xiao-man, WANG Ji-hao, XIE Yan-li. Matrix Microenvironment Mechanics and Cell Biological Behavior. Life Science Research, 2019, 23(6): 487-493.