Abstract:Abstract: p21 is an important cyclin-dependent-kinase inhibitor (CKI) and maintains cell growth and proliferation by regulating the cell cycle. It also participates in the processes of apoptosis, cell senescence and cell movement. In recent years, more and more studies have shown that the function of p21 is dualistic. When p21 is located in the nucleus, it mediates cell cycle arrest and inhibits cell proliferation by inhibiting the activity of cyclin-dependent kinases (CDKs). However, p21 can promote cell proliferation in the cytoplasm. Here, the main biological functions, the regulatory mechanisms of subcellular localization of p21 and its recent advances in tumor research were reviewed.
引用本文:
刘 妍, 邓堂刚, 叶 茂. p21亚细胞定位与肿瘤[J]. 生命科学研究, 2019, 23(6): 501-509.
LIU Yan, DENG Tang-gang, YE Mao. Subcellular Localization of p21 and Tumors. Life Science Research, 2019, 23(6): 501-509.