Abstract:Abstract: Cyclin-dependent kinase (CDK) is a key regulator of cell cycle and transcription. The abnormal regulation of CDK is an important factor in tumorigenesis. CDK12 is one of the cyclin-dependent kinase associated with transcription. CDK12 phosphorylates RNA polⅡCTD serine, and is involved in a variety of cellular physiological processes including DNA damage response, cell proliferation and differentiation, and mRNA splicing and pre-transcriptional mRNA processing. In addition, the mutation of CDK12 will lead to the dysfunction of various cellular processes and increase the instability of genes, which may contribute to tumorigenesis and tumor metastasis. In order to expound the mechanisms of CDK12 in regulating transcription, RNA splicing, cell maturation and differentiation, and DNA damage repair (DDR) among cells, and the effects of CDK12 mutation on normal cells, the main physiological functions of CDK12 and its role in tumorigenesis were reviewed. It would offer more scientific information for anticancer drugs in targeted treatment study.
引用本文:
李晓军, 陶丽梅, 朱占弟, 聂元华, 陈敏学, 王 琛. CDK12主要生理功能与其在肿瘤发生中作用的研究进展[J]. 生命科学研究, 2019, 23(5): 417-424.
LI Xiao-jun, TAO Li-mei, ZHU Zhan-di, NIE Yuan-hua, CHEN Min-xue, WANG Chen. Advances in Main Physiological Functions of CDK12 and Its Role in Tumorigenesis. Life Science Research, 2019, 23(5): 417-424.