Abstract：Abstract: A large number of recent studies revealed that the crosstalk between bile acid and intestinal microbiota had an important influence on the occurrence and development of non-alcoholic fatty liver disease (NAFLD). Bile acids are mainly synthesized in liver cells and can help to promote digestion and absorption of dietary fat after being secreted into the gut, and also play an important role in physiological signaling and metabolic regulation. Therefore, bile acids can affect NAFLD by participating in energy metabolism and inflammatory response. The metabolites (such as bile acids, short-chain fatty acids, endogenous ethanol and trimethylamine, etc.) of intestinal microbiota have important regulatory effects on the metabolic phenotype, immune homeostasis, inflammatory response, and disease progression. Herein, the interactions and communicating mechanism between bile acid synthesis and translocation metabolism and changes of the intestinal microbiota structure were focused, and this will provide novel medical strategies and clinical treating methods towards NAFLD.
引用本文:
杜传德, 张晓晨, 李宗杰. 胆汁酸和肠道菌群相互作用对非酒精性脂肪性肝病的影响[J]. 生命科学研究, 2019, 23(6): 510-516.
DU Chuan-de, ZHANG Xiao-chen, LI Zong-jie. Interactions of Bile Acid and Intestinal Microbiota Influence Development of Non-alcoholic Fatty Liver Disease. Life Science Research, 2019, 23(6): 510-516.
2019, Vol. 23 
