Abstract：Abstract: Atorvastatin and tanshinone ⅡA have been clinically used in the treatment of atherosclerosis, but the synergistic effect of the two is still unclear. To explore whether their combination can enhance the pre-ventive and therapeutic effects of atorvastatin on atherosclerosis in rats, the rats were randomly divided into control group, model group, low (7 mg/kg)-, middle (21 mg/kg)-, and high (63 mg/kg)-dose tanshinone ⅡA groups, atorvastatin group (7 mg/kg), low-dose tanshinone ⅡA (7 mg/kg) + atorvastatin (7 mg/kg) group, and middle-dose tanshinone ⅡA (21 mg/kg) + atorvastatin (7 mg/kg) group. Except for the control group, rats in other groups were intraperitoneal injected with 300 000 IU/(kg·d) vitamin D3 for 4 days and fed with high-fat diet to establish an atherosclerosis model. After 16 weeks, the concentrations of serum total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein choles-terol (LDL-C) in rats were determined. In addition, the pathological changes of abdominal aorta were obser-ved by hematoxylin-eosin staining. The results showed that the concentrations of TC, TG, and LDL-C in sera of atherosclerotic rats were significantly decreased in the combination treatment groups (P<0.01). High-dose tanshinone ⅡA and atorvastatin significantly inhibited intimal thickening of the abdominal aorta, and middle-dose tanshinone ⅡA combined with atorvastatin had the strongest inhibition effect (P<0.01). In con-clusion, the combination of tanshinone ⅡA with atorvastatin exhibits a better treatment effect on atheroscle-rosis in rats.
引用本文:
叶泽森, 周里岩, 黄光业, 薛照芸, 刘培庆, 陈健文. 丹参酮ⅡA联合阿托伐他汀对大鼠动脉粥样硬化的治疗作用研究[J]. 生命科学研究, 2022, 26(2): 95-102.
YE Ze-sen, ZHOU Li-yan, HUANG Guang-ye, XUE Zhao-yun, LIU Pei-qing, CHEN Jian-wen. Study of Therapeutic Effects of Tanshinone ⅡA Combined with Atorvastatin on Atherosclerosis in Rats. Life Science Research, 2022, 26(2): 95-102.
