Abstract:Abstract: G-quadruplex (G4) is a special secondary structure of nucleic acid first observed in vitro. G4 of genomic DNA regulates chromatin structure and state in a variety of ways. It plays an important role in DNA replication, gene transcription, chromatin conformation change and other biological processes. Herein, the basic structural characteristics and functions of G4 DNA (G4-DNA) were summarized. The interaction be-tween G4 and chromatin structure was mainly reviewed, including the enrichment of G4 in the open region of chromatin, the interaction between G4 and epigenetic modification, and the effect of G4 on the higher structure of chromatin. The research in the relationship between G4 and chromatin structure can help further explore the functions of G4, understand the relationship between G4 and diseases, and carry out new drug research with G4 as a target.
引用本文:
杨 婧, 侯 越, 舒慧灵, 孙 啸. G-四链体与染色质结构相互作用关系的研究进展[J]. 生命科学研究, 2022, 26(2): 175-181.
YANG Jing, HOU Yue, SHU Hui-ling, SUN Xiao. Research Progress in Interaction Between G-quadruplex and Chromatin Structure. Life Science Research, 2022, 26(2): 175-181.