Abstract：Abstract: In order to observe the preventive effects of ginsenoside Rg1 on acute hypoxia induced lung in-jury in rats exposed to high altitude and its possible mechanisms, male SD rats were randomly divided into 5 groups, including normal group, model group, positive control group (salidroside), low-dose and high-dose ginsenoside Rg1 groups, 8 in each group. After intragastric administration for 8 consecutive days, the acute hypoxia was established in hypobaric oxygen chamber (simulated altitude of 6 000 m). The wet-dry lung mass ratio, pathological structure, oxidative stress and energy metabolism biochemical indexes and the levels of inflammatory factors were observed. The results showed that, compared with the normal group, the model group had significantly increased wet-dry mass ratio of lung tissue and obvious pathological changes. More-over, the MDA content and NOS activity increased markedly, the CAT and Na+-K+-ATPase activity decreased, and the levels of IL-6 and TNF-α also increased markedly. However, compared with the model group, each treatment group could reduce the wet-dry lung mass ratio, improve pathological changes of lung tissue, re-duce the MDA content and NOS activity, enhance the CAT and Na+-K+-ATPase activity, and reduce the levels of IL-6 and TNF-α. The experimental results demonstrated that ginsenoside Rg1 can effectively pre-vent lung injury in rats with acute hypoxia, and the mechanisms may be related to its roles in anti-oxida-tion, regulation of energy metabolism and anti-inflammation.
引用本文:
查玉杰, 曹丽睿, 罗 芩, 杨 吕, 周金华, 何 庆. 人参皂苷Rg1对高原急性缺氧大鼠肺组织损伤的预防作用[J]. 生命科学研究, 2022, 26(2): 139-144.
ZHA Yu-jie, CAO Li-rui, LUO Qin, YANG Lü, ZHOU Jin-hua, HE Qing. Preventive Effects of Ginsenoside Rg1 on Lung Injury in Rats with Acute Hypoxia at High Altitude. Life Science Research, 2022, 26(2): 139-144.
