Abstract:Abstract: For a long time, only classical actions have been attributed to the skeleton such as protection and stabilization of the body and support in locomotion. In addition, bone is a site for hematopoiesis and serves as a pivotal organ in calcium and phosphorus homeostasis. In recent years, more and more evidence has shown that bone is not only an “inert organ” accepting neurological and humoral regulation, but also an “endocrine organ” with biological activity. Biologically active substances secreted by bone, such as bone regulatory protein, growth factors, adipokines, cytokines, active peptides and hormones, can regulate the metabolism of bone through autocrine and paracrine pathways. It can also act on the target organs or tissues such as the pancreas, liver, kidney, skeletal muscle, brain, testis through telecrine pathway.
引用本文:
李文洲, 解琪琪, 史卫东, 邓亚军, 马玉靖, 谢建琴, 康学文, 汪 静. 骨骼内分泌功能研究进展[J]. 生命科学研究, 2018, 22(6): 483-490.
LI Wen-zhou, XIE Qi-qi, SHI Wei-dong, DENG Ya-jun, MA Yu-jing, XIE Jian-qin, KANG Xue-wen, WANG Jing. Research Progresses on Endocrine Functions of Bone. Life Science Research, 2018, 22(6): 483-490.