Abstract��Abstract: Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells lose many of their epi-thelial traits and acquire various features of mesenchymal cells. EMT is considered as an initial and necessary step by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties. Functional loss of E-cadherin, up-regulated expression of N-cadherin, vimentin and ma-trix metalloproteinases (MMPs) and reorientation of β-catenin from the cell membrane to the nucleus are frequently observed in the tumor cells undergoing EMT. All of the EMT-related transcription factor members in Twist, Snail and Zeb families mediate the invasion and metastasis of tumor cells by promoting EMT.
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ZHANG Qing-yun, FU Jun-jiang, CHEN Han-chun. The Molecular Mechanism of Epithelial-mesenchymal Transition Mediating Tumor Metastasis. Life Science Research, 2018, 22(6): 503-510.