Abstract：Abstract: To explore the function of deleted in lymphocytic leukemia 1 (DLEU1) and its related genes and signaling pathways in bladder cancer progression by bioinformatics analysis, many tools, including Atlas of Genetics and Cytogenetics in Oncology and Haematology, Dcode, NCBI, GWAS Catalog, Targetvalidation, FireBrowse, GEPIA, Multi Experiment Matrix and LinkedOmics, were applied to comprehensively analyze the function of the DLEU1 gene. The gene is located on human chromosome 13q14.2~q14.3 and highly conserved in different species. It is widely expressed in many normal human tissues, and is associated with body height, primary biliary cirrhosis and other biological phenotypes. It is also widely expressed in bladder cancer and many other tumors. Its high expression in bladder cancer is associated with a significant decrease in both overall and disease-free survival rates. The enrichment analysis further found that DLEU1 is closely related to ncRNA metabolic pathways in many tumors including bladder cancer. DLEU1 may be a potential oncogene and therapeutic target for bladder cancer. It is mainly involved in the progression of bladder cancer by regulating ncRNA metabolic pathways.
引用本文:
何富强, 付军明, 郭君其, 朱凌峰. 生物信息学预测lncRNA DLEU1的功能及其在膀胱癌中调控ncRNA代谢途径的作用[J]. 生命科学研究, 2018, 22(6): 445-453.
HE Fu-qiang, FU Jun-ming, GUO Jun-qi, ZHU Ling-feng. Bioinformatics Analysis Predicts the Function of lncRNA DLEU1 and Its Role in Bladder Cancer by Regulating ncRNA Metabolic Process. Life Science Research, 2018, 22(6): 445-453.
