Abstract:Abstract: Baclofen is the only clinically available γ-aminobutyric acid type B receptor (GABAB receptor) ago-nist. There are reports that baclofen has different effects on cognition, but the research results are controver-sial. The paradigms used in these studies include Morris water maze and the radial maze, in which reward and punishment effects are involved. In order to avoid the influence of reward and punishment on the beha-vior of mice, a two-trial Y-maze, which is based on the innate tendency of rodents to explore novel envi-ronments, was used to investigate the effects of baclofen (doses 1.0 mg/kg, 2.5 mg/kg and 7.5 mg/kg) on spatial recognition memory. An open field test was used to assess the behavior performance of mice under the influen-ce of these doses of baclofen. The results showed that the higher doses of baclofen (2.5 mg/kg and 7.5 mg/kg) impaired the memory performance of mice in the Y-maze task, and the highest dose (7.5 mg/kg) decreased the locomotion and exploration of mice in the open field test. In addition, all used doses did not obviously affect the degree of anxiety in mice. These data suggested that baclofen may dose-dependently impair spatial me-mory and its negative effects on cognition should be considered in future clinical trials.
引用本文:
周 正, 宋美慧, 褚光辉, 付 玉. GABAB受体激动剂巴氯芬对小鼠空间识别记忆能力的影响[J]. 生命科学研究, 2022, 26(3): 213-218.
ZHOU Zheng, SONG Mei-hui, CHU Guang-hui, FU Yu. Effect of GABAB Receptor Agonist Baclofen on Spatial Cognition in Mice. Life Science Research, 2022, 26(3): 213-218.