Abstract:Abstract: Most of bacteria have co-evolved with the host in a symbiotic relationship. The structure and quantity of bacteria maintain homeostasis, which can effectively prevent the invasion of harmful bacteria and the occurrence of inflammatory diseases. A number of studies have shown that intestinal flora imbalance may be associated with a variety of diseases, including type 2 diabetes, obesity, cirrhosis, colorectal cancer and rheumatoid arthritis (RA). Studies have shown that intestinal flora is an environmental factor affecting the pa-thogenesis of RA, and one mechanism involved is the imbalance between intestinal flora and mucosal homeostasis, which is not conducive to intestinal adaptive immunity. The formation of the immune system cannot identify resident and pathogenic bacteria, causing mucosal disorders. Another mechanism is that enteric dysbacteriosis will activate immune factors, causing systemic immune responses. Therefore, both local regulation of intestinal mucosa and flora and systemic immune factors participate in the occurrence and development of RA. Herein, the correlation between gut microbiota dysbiosis and RA was reviewed, which would provide a theoretical basis for further research on early prevention and etiological treatment of arthritis.
引用本文:
闫梦真, 余 婕, 董甜甜, 陈桂婷, 周婷婷, 李世刚. 肠道菌群失调引起类风湿关节炎发病的研究进展[J]. 生命科学研究, 2019, 23(2): 168-172.
YAN Meng-zhen, YU Jie, DONG Tian-tian, CHEN Gui-ting, ZHOU Ting-ting, LI Shi-gang. Research Progresses of Gut Microflora Disturbance in Pathogenesis of Rheumatoid Arthritis. Life Science Research, 2019, 23(2): 168-172.