Abstract:Abstract: Preterm birth is the leading cause of infant death. Studying the related factors of preterm birth is of great significance for preventing and controlling its occurrence. Although great progress has been made in the causes, prevention and treatment of preterm birth, its morbidity is still high, and how to prevent and deal with it is still an important problem in perinatal medicine. Infection and/or exaggerated systemic or local inflammation are recognized as a pathophysiological pathway to preterm birth. Intrauterine infection, as one of the pathogenic factors of preterm birth, is often caused by the bacteria ascending from the vaginal microbiome. However, the treatment of various infections has limited efficacy in reducing the risk of preterm birth, suggesting that other complex mechanisms may be involved in its development. Studies have shown that the key mediator of inflammatory responses, the complement system, is an innate defense component that not only protects the body from infection but also plays an important role in coordinating normal development, and is closely related to preterm birth. Exploring the relationships between the complement system and preterm birth, and between microecology and complement markers, can provide a theoretical basis for the potential intervention strategy to inhibit the overactivation of complements and to prevent preterm birth.
引用本文:
张友义, 刘伟娜, 赵慧娜, 徐 晨, 倪 鑫. 补体系统与早产发生的研究进展[J]. 生命科学研究, 2019, 23(2): 140-145.
ZHANG You-yi, LIU Wei-na, ZHAO Hui-na, XU Chen, NI Xin. Advances in Research on Complement System and Preterm Birth. Life Science Research, 2019, 23(2): 140-145.