Abstract：Abstract: Parkinson’s disease (PD) is a common neurodegenerative disease, affecting a vast population. Here, the data involving both gene expression and DNA methylation were analyzed from dopaminergic cells in PD. Genes with different expression levels or DNA methylation levels were identified, and a correlation between those genes and PD was revealed. Genes associated with formation and elongation of microtubule, including SLAIN1, TAGLN3 and TUBB2B, were up-regulated, whereas those related to innate immune system, such as LY96, were down-regulated. Surprisingly, SCG5, which is involved in immune response for PD, was up-regulated. In addition, DNA methylation was found to be highly activated near the transcription start sites. Besides its function in gene transcription, DNA methylation with a high level may cause conformational changes of chromatin structure through affecting PRC1 and PcG complexes. Moreover, those genes may be involved in regulation of axon guidance, neuronal differentiation, migration, intracellular trafficking and other functions. The results provide new insights into better understanding of molecular mechanisms in PD.
引用本文:
罗东辉, 罗 坤, 刘宏德. 帕金森病多巴胺神经细胞的差异表达基因分析[J]. 生命科学研究, 2018, 22(1): 8-13.
LUO Dong-hui, LUO Kun, LIU Hong-de. An Analysis of Differentially Expressed Genes in Dopaminergic Neurons in Parkinson’s Disease . Life Science Research, 2018, 22(1): 8-13.
