Abstract:Abstract: The DNA Ancestry Analyzer Version 1.0, or DAA v1.0, was established based on the probability algorithm, clustering analysis and principal component analysis to infer ancestry for unknown individuals. The basic part of DAA v1.0 was written in Python, R and C; and the front part was written in node.js, HTML, and css. DAA v1.0 can estimate continental ancestry components of unknown individuals and populations. Compared with the previous analysis method, the consistency of DAA v1.0 is 100%, and the efficiency is improved by about 600%. It can calculate the population assignment match probability (AMP), likelihood ratio (LR), population ancestry component and draw the figure of classification of unknown individuals automatically, and has important practical values in the field of human genetics and forensic genetics.
引用本文:
刘 京, 李 盛, 江 丽, 赵 蕾, 赵雯婷, 丰 蕾, 刘海渤, 季安全, 李彩霞. 对于未知来源个体进行族群推断的自动分析系统[J]. 生命科学研究, 2018, 22(1): 3-7.
LIU Jing, LI Sheng, JIANG Li, ZHAO Lei, ZHAO Wen-ting, FENG Lei, LIU Hai-bo, JI An-quan, LI Cai-xia. DNA Ancestry Analyzer: an Automatic Program for Ancestry Inference of Unknown Individuals. Life Science Research, 2018, 22(1): 3-7.