Abstract: Abstract: Down-regulated in renal cell carcinoma 1 (DRR1) was firstly defined as a tumor suppressor gene, because its expression was found to be down-regulated in renal cell carcinoma. Further studies demonstrated that DRR1 is broadly expressed in various tissues, and with the highest level in the nervous system. It plays important roles in maintaining the normal function of nervous system. Moreover, DRR1 also plays a dual role in tumorigenesis. On one hand, the expression of DRR1 is down-regulated in several types of tumors, and its expression level is negatively related to the proliferation ability of tumor cells. On the other hand, the expression level of DRR1 is increased in high grade glioblastoma, and is positively related to the invasion ability of glioblastoma cells. Here, in order to provide related information for future research, the biological roles of DRR1 were discussed in nervous system development and tumorigenesis.
曹振楠, 牟 萍. DRR1生物学功能的研究进展[J]. 生命科学研究, 2019, 23(4): 310-315.
CAO Zhen-nan, MU Ping. The Biological Roles of DRR1. Life Science Research, 2019, 23(4): 310-315.