Abstract:Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by a decline in cognitive function, which mainly affects the individual’s memory and learning abilities. Its pathogenesis is still unclear. There are mainly two core pathologies, amyloid β-protein deposition and neurofibrillary tangles. These protein depositions can cause neuronal dysfunction and cell death through continuous inflammation and oxidative stress. This sustained immune response has been considered the third most pathological fea-ture. Activation of glial cells, continuous activation of other immune cells, production of inflammatory fac-tors, up-regulated or down-regulated expression of some microRNAs, and imbalance of the intestinal flora can all produce or promote neuro-inflammatory responses through different pathways, resulting in neuron damage and aggravation of AD pathology. Herein, the roles and related mechanisms of inflammation-related cells and factors as well as influencing factors in AD are reviewed.
引用本文:
张 薇, 刘 会, 张亚岚, 王满侠. 炎症在阿尔茨海默病中作用机制的研究进展[J]. 生命科学研究, 2021, 25(2): 144-150.
ZHANG Wei, LIU Hui, ZHANG Ya-lan, WANG Man-xia. Research Progresses on Mechanisms of Inflammation in Alzheimer’s Disease. Life Science Research, 2021, 25(2): 144-150.