Abstract:Abstract: Growth arrest and DNA damage-inducible 45A (GADD45A) is the first P53 activated stress-induced gene, which is also a target gene of P63, P73, BRCA1 and MYC. As a DNA damage repair gene, GADD45A is regulated by P53 dependent (induced by ionizing radiation) and P53 independent (induced by ultraviolet light) pathways, and participates in DNA damage repair, cell cycle arrest, apoptosis, autophagy, angiogenesis and other biological functions, which are closely related to tumorigenesis and tumor develop-ment. In the treatment of most tumors, chemotherapeutics directly or indirectly (e.g. demethylation and acety-lation) upregulates GADD45A expression and improves the drug sensitivity of cancer cells. Meanwhile, over-expression of GADD45A can interfere with radiation resistance during radiotherapy. However, for a few tu-mors, the expression of GADD45A can increase the survival rate of cancer cells. Here the roles and mecha-nism of GADD45A in tumor therapy are mainly reviewed.
引用本文:
胡晓红, 杨力芳, 李 丹. GADD45A与肿瘤治疗[J]. 生命科学研究, 2021, 25(2): 124-130.
HU Xiao-hong, YANG Li-fang, LI Dan. GADD45A and Tumor Therapy. Life Science Research, 2021, 25(2): 124-130.