Abstract: Abstract: Triclosan (2,4,4’-trichloro-diphenylurea, TCS) is one of the most widely used emerging environ-mental contaminants in the environment, and it can be strongly adsorbed in soil, sediments, and colloids. The bioaccumulation of TCS makes its concentration in organisms far exceed those in water, soil and other environments. TCS is able to enter the food chain through bioaccumulation. Herein, zebrafish (Danio rerio) embryos were used as the model to discuss the effects of different concentrations of TCS on the development of zebrafish embryos and larvae. The results showed that TCS exposure had obviously teratogenic and lethal effects on zebrafish embryos and larvae. In order to further understand the effects of TCS on the ocular microstructures of zebrafish, the sections were made and observed by transmission electron microscopy. It showed that the number of extracellular photosensitive nodes in the eyes of zebrafish larvae was significantly reduced after TCS exposure. The outer reticular and intramural layers were significantly thinner and showed more severe vacuolation than those in the control group. The pyknosis was severe as well, even some nuclei of the outer nuclear layer dissolved. These results indicated that TCS exposure may have potential toxic effects on eye development of zebrafish larvae. This provides a scientific basis for further exploring the potential toxic effects of TCS on human body.
张 灵, 刘 秘, 王雯雯, 叶嘉星, 方周溪, 王慧利, 周志明, 艾为明. 三氯生单独暴露对斑马鱼幼鱼眼部的毒性研究[J]. 生命科学研究, 2019, 23(4): 290-296.
ZHANG Ling, LIU Mi, WANG Wen-wen, YE Jia-xing, FANG Zhou-xi, WANG Hui-li, ZHOU Zhi-ming, AI Wei-ming. Toxic Effect of Triclosan Exposure on the Eyes of Zebrafish Larvae. Life Science Research, 2019, 23(4): 290-296.