Abstract:Abstract: Tuberculosis (TB), especially pediatric TB, remains an important global health concern. Due to poor sensitivity and specificity of traditional TB diagnostic techniques, TB cases cannot be accurately and timely diagnosed, leading to delayed treatment for patients. The low bacterial load and inability to cough up sputum in children make TB diagnosis more challenging in children than in adult. Lipoarabinomannan (LAM), an anti-gen on the cell wall of Mycobacterium tuberculosis (MTB), is found in the urine of TB patients, and detection of urine LAM is helpful to diagnose TB quickly and accurately. Herein, the research progress of LAM assay for TB diagnosis in children is reviewed.
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王尉蓉, 范雨鑫, 孔 璟, 刘玫肖, 陈晶晶, 高 利, 吴新雅, 柳爱华, 宝福凯. 结核分枝杆菌脂阿拉伯甘露聚糖尿检用于儿童结核病诊断的研究进展[J]. 生命科学研究, 2022, 26(6): 522-527.
WANG Wei-rong, FAN Yu-xin, KONG Jing, LIU Mei-xiao, CHEN Jing-jing, GAO Li, WU Xin-ya, LIU Ai-hua, BAO Fu-kai. Research Progress of Urine Lipoarabinomannan Test in Tuberculosis Diagnosis in Children . Life Science Research, 2022, 26(6): 522-527.