Abstract:Abstract: Kinship inference based on short tandem repeat (STR) and single nucleotide polymorphism (SNP) is widely used in population genetics, forensics and other fields, but there is no mature system that can realize automatic batch processing of STR and SNP data. To fill this gap, a DNA pedigree inference system based on STR and SNP data (named DNA Genealogy Analyzer Version 1.0, DGA v1.0) was developed, which can use STR and SNP relationship prediction algorithms to calculate all kinships in the group of unknown rela-tives. The core algorithm part of the system is implemented based on Python language, the front-end part is written in HTML and CSS language, and the whole is developed using Python Flask framework. Compared with the existing analysis methods, the system has 100% result consistency and its computing efficiency is increased by more than 800%. The system would have important application value in population genetics and other fields.
引用本文:
张文杰, 李彩霞, 于 迪, 管珊珊, 童梦洁, 范 虹, 刘 京. 对未知关系个体进行系谱推断的自动分析系统[J]. 生命科学研究, 2022, 26(6): 515-521.
ZHANG Wen-jie, LI Cai-xia, YU Di, GUAN Shan-shan, TONG Meng-jie, FAN Hong, LIU Jing. An Automatic Analysis Software System for Forensic DNA Pedigree Inference. Life Science Research, 2022, 26(6): 515-521.