Abstract:Abstract: In order to study the laws of influenza epidemics, a new method was proposed for revealing the ability of influenza virus to survive in its environment and estimating the virus biodiversity. Based on 99 861 sequences of hemagglutinin proteins worldwide from 1902 to 2016, cluster analysis was adopted to obtain the number of optimal structural clustering by applying 40-dimensional feature vectors of the sequences and constructing hierarchical clusters of each year’s influenza viruses. Furthermore, the population entropy was calculated for expressing biodiversity based on the indices for biodiversity assessment. Through analysis of the historical data, the biodiversity evaluation by using population entropy proved entirely matching with the time of influenza epidemics. Hence, this method can provide the basis for predicting influenza epidemics.
引用本文:
周加兴, 唐旭清. 基于生物多样性的流感暴发研究[J]. 生命科学研究, 2018, 22(2): 87-92.
ZHOU Jia-xing, TANG Xu-qing. Research on Influenza Epidemics Based on Biodiversity. Life Science Research, 2018, 22(2): 87-92.