Abstract:Abstract: Not only can stable isotope tracer-based metabolomics detect the alteration of metabolites during the development and treatment of diseases, but also quantitatively analyze metabolites and describe the metabolic characteristics of biological system. Recent advances in stable isotope tracer-based metabolomics approaches enable unambiguous tracking of individual atoms through compartmentalized metabolic networks directly in human subjects, therefore it’s a tool to find important biomarkers for identifying etiology of diseases, diagnosing diseases and therapeutic evaluation of medicines. Herein, a brief overview of applications of stable isotope tracer-metabolomics in clinical research was performed with the aim of offering a significant basis for better clinical development of metabolomics.
引用本文:
高英慧, 冯一丹, 唐智言, 马 艳, 张学梅, 段 薇. 基于稳定同位素的代谢组学临床研究进展[J]. 生命科学研究, 2017, 21(6): 558-564.
GAO Ying-hui, FENG Yi-dan, TANG Zhi-yan, MA Yan, ZHANG Xue-mei, DUAN Wei. Stable Isotope Tracer-Based Metabolomics and Applications for Clinical Research. Life Science Research, 2017, 21(6): 558-564.