Abstract:Abstract: Ribosomal proteins (RPs) not only participate in the synthesis of proteins in cells, but also have a variety of extraribosomal functions. The ribosomal protein S26 (RPS26) locates in the small subunit of ribosome, and its dysfunction is closely related to many diseases. Recent researches on RPS26 include the ribosomal functions such as participating in ribosome assembly, and extraribosomal functions such as participating in the nonsense-mediated mRNA decay (NMD), and directly or indirectly regulating the expression of the important tumor suppressor gene p53. Several reports confirmed that RPS26 gene mutations cause Diamond-Blackfan anemia (DBA), and the relationship of RPS26 gene and type 1 diabetes (T1D) is still controversial. Exploring the role of RPS26 involved in NMD, which leads to DBA, helps to understand the pathogenesis of DBA, and also improve the efficiency of gene therapy with SMaRT (spliceosome-mediated RNA trans-splicing) method. In addition, the role of RPS26 in tumor formation is also worth exploring.
引用本文:
王枭宇, 梁 超, 方肇勤. 核糖体蛋白S26的研究进展[J]. 生命科学研究, 2017, 21(5): 450-453.
WANG Xiao-yu, LIANG Chao, FANG Zhao-qin. Research Progress of Ribosomal Protein S26. Life Science Research, 2017, 21(5): 450-453.