Abstract：Abstract: Nestin, a neural stem cell marker taking part in tissue regeneration, is expressed in some types of tumor cells. It was reported that nestin may be closely related to malignant cell proliferation and migration. In a mouse model of acute lymphoid leukemia (ALL), leukemia-propagating cells (LPCs), in response to chemotherapy, could build a protective niche surrounded by sheaths of supporting cells containing nestin-positive cells. To study the clinical expression of nestin gene in leukemia patients, the nestin expression in 50 patients (38 AML and 12 CML) was tested by RT-PCR and Western-blot. The results showed that nestin mRNA was expressed in most of the patients (42/50), but nestin protein was expressed in 6 patients. The expression level of nestin mRNA in patients with AML or CML was not associated with the levels of the hemoglobin, thrombocyte, cytokines as well as T-lymphocytes. The overexpression of nestin mRNA was strongly correlated with the hyperleukocytosis myeloid leukemia. Nestin expression in AML and CML was not related with complete remission (CR). It provides important information that abnormal expression of nestin mRNA may be a biomarker of myeloid leukemia.
引用本文:
王艳飞, 梅 芬, 沈 涛, 李 丽, 陆 洁, 赵仁彬, 杨同华, 撒亚莲. Nestin基因在髓系白血病的表达及意义[J]. 生命科学研究, 2016, 20(5): 413-417.
WANG Yan-Fei, MEI Fen, SHEN Tao, LI Li, LU Jie, ZHAO Ren-Bin, YANG Tong-Hua, SA Ya-Lian. Expression and Role of Nestin in Acute Myeloid Leukemia. Life Science Research, 2016, 20(5): 413-417.
2016, Vol. 20 
