Abstract：Abstract: Myofibroblasts, which have excellent stress sensitivity and matrix synthesis, play an important role in fibrotic diseases and scar contracture. This type of fibroblasts also exists in periodontal ligament and shows a significant increase during tooth movement, which probably performs vital functions in periodontal tissue remodeling. Here, the features, functions, sources of differentiation of myofibroblasts were introduced, and the biological basis for myofibroblast functions, and signaling pathways and their crosstalk related to mechanical stimulation, were summarized. Based on those characteristics, it showed that myofibroblasts may play a role in orthodontic force transmission and periodontal tissue remodeling, and that tooth movement may influence the differentiation of myofibroblasts in periodontal ligament. It is expected that new thoughts could be brought to the studies on functional mechanism of myofibroblasts and orthodontic tooth movement.
引用本文:
项自超, 何依若, 王鸿哲, 白 丁. 正畸牙移动中的潜在新角色：牙周膜肌成纤维细胞[J]. 生命科学研究, 2016, 20(4): 371-376.
XIANG Zi-Chao, HE Yi-Ruo, WANG Hong-Zhe, BAI Ding. A Potential New Star in Orthodontic Tooth Movement: Myofibroblasts in Periodontal Ligament. Life Science Research, 2016, 20(4): 371-376.
2016, Vol. 20 
