Abstract：Abstract: The effects of social isolation (social deprivation) on behavioral and neuroendocrine responses have been widely studied in prosocial animals. However, little is known about whether post-weaning isolation exerts similar effects in asocial animals, and whether there are sex-specific differences in these effects. BALB/c mice are generally less sociable. In order to investigate aforementioned question, weanling male and female BALB/c mice were singly or group housed for six weeks, then anxiety levels, locomotion and social behaviors were examined using an open field test and the same-sex social interaction test, and the concentrations of serum corticosterone (CORT), norepinephrine (NE) and oxytocin (OT) were measured using ELISA. The results showed that single rearing resulted in an increase in the social investigation behavior in both sexes compared to group rearing. Furthermore, the females experiencal single rearing enhanced the anxiety levels, while the males experienced single rearing increased the locomotion and the aggressive behavior, and decreased the contact behavior. Along with these changes, single rearing aggravated the levels of serum CORT in both sexes, while serum NE and OT were increased only in females. Taken together, these results indicate that post-weaning isolation results in sex-specific changes in behaviors and stress endocrine in asocial animals, which might be associated with the release differences of NE and OT.
引用本文:
刘朝宝, 王建礼, 詹 泊. 断乳后隔离对BALB/c小鼠的焦虑水平、社会行为及血清应激激素影响的性别差异[J]. 生命科学研究, 2016, 20(4): 325-332.
LIU Chao-Bao, WANG Jian-Li, ZHAN Bo. Sex Differences in Post-weaning Isolation Induced Anxiety Levels, Social Behaviors and Serum Stress Hormones in BALB/c Mice. Life Science Research, 2016, 20(4): 325-332.
2016, Vol. 20 
