Abstract:Abstract:As a cell signal, calcium ion(Ca2+) plays a significant role in mitochondrial dysfunction and cell apoptosis. In recent years, among the increasing amount of studies about Ca2+ channels and its related regulatory proteins, the structure of mitochondrial uniporter complex and the distribution of its related proteins have become a major focus. Mitochondrial calcium uniporter (MCU), as a pivotal channel protein in the uniporter complex, transfers Ca2+ from cytoplasm to mitochondrial matrix and controls its rate by electrochemical gradient. It has great significance in intracellular Ca2+ signal transduction, Ca2+ homeostasis, mitochondrial energy metabolism and apoptosis. Identifying MCU and its regulatory proteins not only illuminates the occurrence and development of mitochondrial oxidative stress in related diseases, but also provides important theoretical references for further treatment.
引用本文:
杨 洁, 闾宏伟. 线粒体钙单向转运体和线粒体应激关系的研究进展[J]. 生命科学研究, 2016, 20(2): 178-182.
YANG Jie, 闾Hong-Wei . Progresses on Relationship Between Mitochondrial Calcium Uniporter and Mitochondrial Oxidative Stress. Life Science Research, 2016, 20(2): 178-182.