Abstract：Abstract: As a newly revealed antiviral factor, SAMHD1 has been focused for years in molecular biology research, but it’s antiviral mechanism remains unclear. Previous studies have revealed some possible antiviral mechanisms including dNTPase activity and the un-phosphorylation of T592 residue. With the continuous research in the past two years, the capabilities of SAMHD1 for degrading RNA and maintaining genome stability were also reported. Meanwhile, the oligomer structure of SAMHD1 remained attractive to the researchers. New discovery kept being made on the native oligomerized structure and the mechanism of tetramer formation of SAMHD1, with the crystal structure changed from the initially determined dimer to recently confirmed endogenous GTP as the activator to form an activated homotetramer. Combining all known biological function and structural information, a deep and comprehensive analysis on the antiviral mechanism of SAMHD1 is provided based on the latest published researches.
引用本文:
侯靖威, 杜 娟, 郑雯雯, 于晓方. SAMHD1蛋白抗病毒作用机制研究的新进展[J]. 生命科学研究, 2016, 20(1): 76-81.
HOU Jing-Wei, DU Juan, ZHENG Wen-Wen, YU Xiao-Fang. Advances in the Antiviral Mechanism Research of SAMHD1. Life Science Research, 2016, 20(1): 76-81.
2016, Vol. 20 
