Abstract:Abstract: The Wg/Wnt signaling pathway plays critical roles in an array of biological processes, especially in the regulation of cardiac development and dysfunction. The pygopus gene (pygo) is a new member of the canonical Wnt signaling pathway and was reported to be a regulator in cardiac development through Wnt signaling. However, pygo has also been implicated in Wnt-independent roles in the regulation of adult heart function. Here, the progresses on pygo’s function in cardiac development and aging as well as its molecular regulatory mechanisms in Drosophila and mammals are fully discussed. Although the functions of pygo on adult heart were independent of Wnt signaling, TCF-like mediators may cooperate with this function, since a TCF dominant negative mutation (TCF-DN) severely blocked adult heart physiological activities and performed the similar phenotype as pygo. pygo may also interact directly with Wnt signal targets, such as ubx, by jumping over TCF or Lgs. Another mechanism of pygo’s function on adult heart may be associated with histone modification. It was reported that Pygo protein could interact with Lgs and form Pygo-BCL9/Lgs-H3k4me compounds to regulate Wnt targets. In addition, Pygo protein could also combined the core element WDR5 of methyltransferase HMT to facilitate the combination of PHD domain and H3K4, suggesting that pygo regulations to cardiac function are correlative with epigenetic modification.
引用本文:
朱莎莎, 吴秀山, 袁婺洲. pygo基因对心脏功能的调控及其研究进展[J]. 生命科学研究, 2016, 20(1): 57-62.
ZHU Sha-Sha, WU Xiu-Shan, YUAN Wu-Zhou. Regulation on Heart Function and Related Research Progression of Gene pygo. Life Science Research, 2016, 20(1): 57-62.