SARS-CoV-2感染机制分析与COVID-19治疗药物研究进展

王康泓

生命科学研究 ›› 2020, Vol. 24 ›› Issue (6) : 442-451.

PDF(453 KB)
PDF(453 KB)
生命科学研究 ›› 2020, Vol. 24 ›› Issue (6) : 442-451.
新冠肺炎专栏

SARS-CoV-2感染机制分析与COVID-19治疗药物研究进展

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Research Progress of SARS-CoV-2 Infection Mechanisms and COVID-19 Therapeutic Medicines

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摘要

摘 要: 具有潜伏期长、感染性强、人群普遍易感和传播方式多样等特点的严重急性呼吸综合征冠状病毒2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)已在全球多个国家流行。然而, 当下并没有相关的特效药物和疫苗能对其引发的2019冠状病毒病 (coronavirus disease 2019, COVID-19)进行针对性预防和救治。目前, 针对SARS-CoV-2及其引发的COVID-19的相关理论研究和临床分析已取得了一定进展。本文就SARS-CoV-2的基因组分析与溯源、受体血管紧张素转换酶Ⅱ (angiotensin converting enzyme 2, ACE2)与病毒入侵过程和致病过程的关系以及当前COVID-19治疗药物等3个方面的研究进行综述, 以期为疫情后续发展存在的风险和COVID-19相关潜在药物的寻找提供参考。

Abstract

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been prevalent among more than 200 countries around the world. It has a long incubation period, strong infectivity, and various modes of transmission. People are generally susceptible to it. At present, there are no specific drugs and vaccines that can treat or prevent the coronavirus disease 2019 (COVID-19) caused by the virus. However, notable progress has been achieved in theoretical researches and clinical analysis of SARS-CoV-2 and COVID-19. This arti-cle summarized the viral genome and origin analysis, the relationship between the receptor angiotensin con-verting enzyme 2 (ACE2) and the viral infection and pathogenesis, as well as current COVID-19 therapeutic drugs, in hope of providing a reference for awareness of future epidemic risks and searching for potential an-tiviral drugs.

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王康泓. SARS-CoV-2感染机制分析与COVID-19治疗药物研究进展[J]. 生命科学研究, 2020, 24(6): 442-451
WANG Kang-hong. Research Progress of SARS-CoV-2 Infection Mechanisms and COVID-19 Therapeutic Medicines[J]. Life Science Research, 2020, 24(6): 442-451

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