Abstract:Abstract: As the coronavirus disease 2019 (COVID-19) is spreading around the world rapidly, recovered COVID-19 patients with retest positive (RP) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA have been reported in many countries. However, the mechanisms of this re-positive test result remain unknown. A case-control study was performed on 153 COVID-19 patients, who had been admitted to three medical institutions in Shiyan City, Hubei Province, from January 24 to April 1, 2020. The demo-graphic features, epidemiological history, laboratory tests, clinical manifestations and chest computed tomog-raphy (CT) examination results were analyzed. Univariable and multivariable Logistic analyses were used to explore the characteristics and risk factors in RP patients. There were significant differences between the RP patients and patients with retest negative (RN) in white blood cell, neutrophil and red blood cell counts, serum hemoglobin, erythrocyte sedimentation rate (ESR), procalcitonin (PCT), lactate dehydrogenase, creatine kinase, albumin, D-dimer and fibrinogen levels, fever levels, length of hospitalization, viral shedding duration and length of absorption in CT image on admission and lymphocyte counts before discharge. Particularly, multi-variate Logistic analysis showed that the fever level, D-dimer level, ESR and length of hospitalization were independent risk factors for RP patients. In addition, RP patients with low levels of albumin were more likely to have symptoms. The above results showed that clinicians should evaluate the probability of re-positive for discharged COVID-19 patients based on the clinical data on admission. It is important to conduct redup-licative nucleic acid tests in discharged COVID-19 patients during the 14-day quarantine and regular fol-low-up observations. Closer monitoring and more nutritional support should be given to those with higher fever, ESR and serum D-dimer levels, as well as longer hospital stays.
引用本文:
胡雯雯, 王梅芳, 常 婵, 刘 岩, 梁丽娴, 邓平基, 郭公孙, 唐以军. 新型冠状病毒肺炎患者核酸检测“复阳”的特点及危险因素分析(英文)[J]. 生命科学研究, 2020, 24(6): 431-441.
HU Wen-wen, WANG Mei-fang, CHANG Chan, LIU Yan, LEUNG Lai-han Elaine, DENG Ping-ji, GUO Gong-sun, TANG Yi-jun. Analysis of Characteristics and Risk Factors for Recovered COVID-19 Patients with Retest Positive for SARS-CoV-2 RNA. Life Science Research, 2020, 24(6): 431-441.