Abstract:Abstract:Alzheimer′s disease (AD) is a chronic neurodegenerative disease in the CNS, the pathological features of which is characterized by senile plaques and neurofibrillary tangles. And its pathogenesis is very complex. TanshinoneⅡA is a liposoluble constituent extracted from Salvia miltiorrhiza, a kind of Chinese herbal medicine, and has a wide range of biological activities. Recent studies have found that tanshinoneⅡA plays an important role in the prevention and treatment of AD by inhibiting the aggregation of β-amyloid protein, suppressing hyperphosphorylation of tau, and protecting neuronal cells from death. Combined with the latest research progress, the pathogenesis of AD and the prevention and treatment effects of tanshinoneⅡA on AD were reviewed, and the basis for further development and utilization of this plant extract was also provided.
引用本文:
李筱筱, 武雪玲, 张 凯, 栗 磊, 孙雅煊. 丹参酮ⅡA对阿尔兹海默病防治作用的研究进展[J]. 生命科学研究, 2017, 21(1): 59-63.
LI Xiao-Xiao, WU Xue-Ling, ZHANG Kai, LI Lei, SUN Ya-Xuan. Research Progress of TanshinoneⅡA in Prevention and Treatment of Alzheimer′s Disease. Life Science Research, 2017, 21(1): 59-63.