The Influence of Baicalein on Heart and Kidney Injury in a Mouse Model of Chronic Hyperuricemia

YANG Yang, YAN Cai-xin, LIN Cui-ting, HUANG Qing-hua, ZHANG Le-qi, ZHENG Qiang, WU Ting, PANG Jian-xin

Life Science Research ›› 2022, Vol. 26 ›› Issue (2) : 111-116.

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PDF(21711 KB)
Life Science Research ›› 2022, Vol. 26 ›› Issue (2) : 111-116.

The Influence of Baicalein on Heart and Kidney Injury in a Mouse Model of Chronic Hyperuricemia

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Abstract: Hyperuricemia (HUA) is an important risk factor for the incidence and development of heart and kidney diseases. Urate-lowering therapy is the primary treatment for HUA. We previously discovered natural product baicalein (BAL) showing urate-lowering effect. Herein, effects of BAL on heart and kidney were as-sessed in a chronic HUA mouse model induced by co-administration of potassium oxonate and hypoxanthine for 8 weeks. Mice treated with allopurinol (AP) were used as positive control. The results showed that BAL ameliorated HUA associated cardiac hypertrophy, myocardial fiber disarray and interstitial fibrosis, which was consistent with AP in terms of efficacy. However, unlike AP, BAL didn’t ameliorate HUA associated re-nal function decline, glomerular basement membrane thickening and tubular dilation. It indicated that BAL may protect heart in HUA while not contribute to kidney protection. This study may provide useful informa-tion for BAL application in research of HUA with heart or kidney diseases.

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YANG Yang, YAN Cai-xin, LIN Cui-ting, et al. The Influence of Baicalein on Heart and Kidney Injury in a Mouse Model of Chronic Hyperuricemia[J]. Life Science Research, 2022, 26(2): 111-116
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