The Relationship Between Conformational Changes of C-reactive Protein and Atherosclerosis

SHEN Zhi-yuan, ZHANG Lin

Life Science Research ›› 2020, Vol. 24 ›› Issue (6) : 504-510.

PDF(519 KB)
PDF(519 KB)
Life Science Research ›› 2020, Vol. 24 ›› Issue (6) : 504-510.

The Relationship Between Conformational Changes of C-reactive Protein and Atherosclerosis

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Abstract

Abstract: Inflammation plays an important role in the development of atherosclerosis (AS). C-reactive pro-tein (CRP) is a typical acute phase protein and inflammatory marker factor. A large number of studies have shown that CRP is not only a predictor of cardiovascular disease (CVD) risk, but may also be a regulator. There are two main forms of CRP, namely pentameric CRP (pCRP) and monomeric CRP (mCRP). Herein, the existing research results of CPR were summarized and analyzed, and it was found that the functional activity of CRP is related to its conformation. Furthermore, the allosteric structure of CRP in AS and local inflamma-tion as well as its related mechanisms were expounded. This may provide suggestions and references for comprehensive understanding of the CRP role in AS and for its future research.

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SHEN Zhi-yuan, ZHANG Lin. The Relationship Between Conformational Changes of C-reactive Protein and Atherosclerosis[J]. Life Science Research, 2020, 24(6): 504-510
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