Exosomes as Potential Markers for Diagnosis of Mycobacterium tuberculosis Infection
1. Department of Laboratory Medicine, Kunshan Hospital Affiliated to Jiangsu University, Kunshan 215300, Jiangsu, China;
2. College of Clinical and Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, Shandong, China; 3. Changchun Center for Disease Control and Prevention, Changchun 130000, Jilin, China
Abstract：Exosomes are vesicular structures with a diameter of 30~150 nm, and play critical roles in im-mune regulation and intercellular communication by carrying various bioactive substances such as lipids, proteins, mRNAs, and non-coding RNAs. In recent years, accumulating studies have revealed that exosomes actively participate in the occurrence and development of Mycobacterium tuberculosis infection. Moreover, exosomal components, as potential biomarkers of M. tuberculosis infection, have the characteristics of strong specificity and good stability, and play an important role in diagnosis, therapeutic efficacy evaluation, and prognosis of tuberculosis. Herein, the values of exosomes as diagnostic markers and their potential roles in tuberculosis are reviewed, aiming to provide a theoretical basis for their application as diagnostic biomarkers.
王 楠, 吴建红, 李玉洁, 郑志焕, 姚丽洪, 王建军. 外泌体作为诊断结核分枝杆菌感染的标志物研究[J]. 生命科学研究, 2024, 28(1): 33-40.
WANG Nan, WU Jianhong, LI Yujie, ZHENG Zhihuan, YAO Lihong, WANG Jianjun. Exosomes as Potential Markers for Diagnosis of Mycobacterium tuberculosis Infection. Life Science Research, 2024, 28(1): 33-40.
