Research Progress of Exosomal miRNAs and Their Roles in Pulmonary Fibrosis
Conservation and Utilization of Special Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, Ningxia, China
Abstract：Exosomes are nano-sized lipid bilayer vesicles that are fused by the cell membrane and multi-vesicles and released into the extracellular space by exocytosis. Exosomes play an important role in intercel-lular communication. MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs consisting of 18~24 nucleotides. miRNAs play an important role in the regulation of post-transcriptional gene expression. Pul-monary fibrosis is an irreversible and progressive chronic lung disease. Many studies have shown that abnor-mal expression of exosomal miRNAs is closely related to the development of pulmonary fibrosis. This review focuses on the biological characteristics of exosomes and miRNAs, and discusses the important roles of exo-somal miRNAs in pulmonary fibrosis and their potential as a novel biomarker in this disease.
王泽华, 张丽昀, 张浩澜, 胡成博, 马春燕. 外泌体miRNA及其在肺纤维化中的作用研究进展[J]. 生命科学研究, 2023, 27(1): 9-15.
WANG Zehua, ZHANG Liyun, ZHANG Haolan, HU Chengbo, MA Chunyan. Research Progress of Exosomal miRNAs and Their Roles in Pulmonary Fibrosis. Life Science Research, 2023, 27(1): 9-15.
