Research Progress of Radiation-induced Epigenetic Changes Based on Three-dimensional Culture Model
1. College of Life Sciences, Northwest Normal University, Lanzhou 730070, Gansu, China; 2. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China
Abstract：Compared with the traditional monolayer culture, three-dimensional cell culture (TDCC) can more accurately simulate the growth environment of cells in vivo. In recent years, TDCC has been increasingly used in basic biological research. Epigenetic modification is closely linked to many cellular processes such as cell canceration. Radiation is one of the main means of tumor radiotherapy, the process of which is often accompanied by dynamic epigenetic changes, leading to DNA methylation, chromatin remodeling, histone modification and regulation of non-coding RNA. Exploring the mechanism of radiation-induced epigenetic regulation based on TDCC model is of great significance for treatment and protection of cancer patients.
刘 雁, 杜亚蓉, 孙 坤. 基于三维培养模型的辐射诱导表观遗传改变研究进展[J]. 生命科学研究, 2023, 27(3): 223-228.
LIU Yan, DU Yarong, SUN Kun. Research Progress of Radiation-induced Epigenetic Changes Based on Three-dimensional Culture Model. Life Science Research, 2023, 27(3): 223-228.
