Abstract:Abstract: The hair follicle is a particular skin appendage organ of mammals and undergoes the cycle of an-agen, catagen, and telogen, which is regulated by a series of genes and other related factors. Now, great progress has been achieved in research on the growth, development and regulation mechanisms of hair follicles, especially activation, proliferation and differentiation of hair follicle stem cells. Herein, the periodic growth of hair follicles was introduced, and the research progresses of melatonin, hair follicle-related genes and signaling pathways were summarized. The regulation mechanisms of non-coding RNA and other related proteins/cells involved in hair follicle periodic growth were also concluded. The review provides reference for constructing molecular regulatory network of hair follicle growth and development and for further studying regulation mechanisms of periodic hair follicle growth. It also provides theoretical basis for using modern molecular biotechnology to improve the quality of animal wool/hair.
引用本文:
张 稳, 刘罗兰, 冯登侦, 李新海. 哺乳动物毛囊周期性生长调控机制的研究进展[J]. 生命科学研究, 2021, 25(3): 240-248.
ZHANG Wen, LIU Luo-lan, FENG Deng-zhen, LI Xin-hai. Advances in Regulatory Mechanisms of Mammalian Hair Follicle Periodic Growth. Life Science Research, 2021, 25(3): 240-248.