Abstract��Abstract: To study the regulatory roles of hydrogen water (HW) on main organ and liver injuries caused by high fat and high sugar, rats were fed with high-fat and high-sugar diet, and drenched with HW via intragastric administration, then their appearance of the main organs and organ indexes of thymus, spleen, liver, kidney and heart were observed. The pathological changes of liver were observed by eosin-hematoxylin staining, and the enzyme activities, including aminotransferases, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and the content of malondialdehyde (MDA) in sera of rats were measured. Results showed that the spleen index of rats fed high-fat and high-sugar diet plus HW increased 66.67% (P<0.05), while the liver index decreased 23.31% (P<0.05), compared with those of rats fed high-fat and high-sugar diet plus ddH2O. Vacuolar degeneration in liver occurred in the group of rats fed high-fat and high-sugar diet plus ddH2O group, but no histopathological abnormalities were found in other groups. The activities of glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) in sera of rats fed high-fat and high-sugar diet plus HW decreased 44.10% (P<0.01) and 27.04% (P<0.01), respectively, compared with those of rats fed high-fat and high-sugar diet plus ddH2O. Meanwhile, the activities of SOD, CAT, GSH-Px rose 45.07% (P<0.01), 89.94% (P<0.01) and 61.11% (P<0.01), respectively, and the content of MDA dropped 31.00% (P<0.05). In conclusion, drinking hydrogen water may protect immune system and liver from damages caused by high-fat and high-sugar diet via improving body��s antioxidant capacity in a certain degree.
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����ϼ, �½���, ������, ��ѩ��, ����ɽ, ����ϼ. ��ˮ�Ը�֬��������ι��������Ҫ���������˵ĵ�������[J]. ������ѧ�о�, 2021, 25(3): 202-208.
LI Wei-xia, CHEN Jian-hua, GUO Xu-li, WANG Xue-ling, CHEN Tian-shan, LIU Xiao-xia. Regulatory Effects of Hydrogen Water on Main Organ and Liver Injuries in Rats Fed High-fat and High-sugar Diet. Life Science Research, 2021, 25(3): 202-208.
