Abstract:Abstract: Digestive system neoplasms are malignant tumors caused by multiple factors and gene abnormalities. They are closely related to the abnormal epigenetic modification of the involved genes. Enhancer of zeste homolog 2 (EZH2) is a core subunit of polycomb repressive complex 2 (PCR2) and also a negative regulator for epigenetic modification. It can silence the expression of tumor suppressor genes through catalyzing histone H3K27 methylation. In recent years, EZH2 was found to be highly expressed in digestive system neoplasm tissues and cell lines, which is significantly and positively correlated with neoplasm proliferation, invasion and metastasis, and can be used as an independent poor prognostic indicator for neoplasm patients. Further researches on the relationship between EZH2 and digestive system neoplasms will provide new molecular targets and approaches in treatment of cancers in the digestive system.
引用本文:
吕亚丰, 王艳林. EZH2在消化系统肿瘤发生发展中的作用[J]. 生命科学研究, 2016, 20(3): 278-282.
吕Ya-Feng , WANG Yan-Lin. The Role of EZH2 in the Pathogenesis of Digestive System Neoplasms. Life Science Research, 2016, 20(3): 278-282.