Abstract:Abstract: Circular RNAs (circRNAs) are a kind of circular non-coding RNAs, formed by non-classical reverse splicing. They are expressed abundantly in organisms, highly conservative, specific in tissues and develop-mental stages, and more stable than linear RNA. They play a variety of biological functions, such as gene epigenetic regulation, cell communication, protein translation, etc. Recent studies have shown that, in animal models of depression, circRNAs can affect the activation and function of astrocytes and microglia, and are even related to neuronal development, synaptic growth and expression of nerve growth factors. This article re-views the biological characteristics and functions of circRNAs and their research progress in depression.
引用本文:
谭桂凤, 肖颂华, 张 涵, 冯文辉, 刘中霖. 环状RNA在抑郁症中的研究进展[J]. 生命科学研究, 2021, 25(6): 509-513.
TAN Gui-feng, XIAO Song-hua, ZHANG Han, FENG Wen-hui, LIU Zhong-lin. Research Progress of Circular RNAs in Depression. Life Science Research, 2021, 25(6): 509-513.