Abstract:Abstract: Parkinson’s disease (PD) is a neurodegenerative disease characterized by dopaminergic neuronal loss in the substantia nigra. At present, motor symptoms can be alleviated clinically, but there is no effective way to prevent and reverse the progression of PD. Neural stem cells are a group of pluripotent cells capable of self-renewal, proliferation and differentiation in animal brains. In recent years, there has been much evi-dence proving that there are neural stem cells in PD patients and animal models, which can generate new dopaminergic neurons in a particular condition. Therefore, promoting the regeneration of neural stem cells has a great potential for rescuing the loss of dopaminergic neurons and relieving motor symptoms, which maybe a powerful weapon in PD treatment. This review summarized the proliferation and differentiation of neural stem cells in PD patients and animal models. It may provide novel ideas for the neurogenic therapy of PD.
引用本文:
吴 铮, 任志伟, 张国君. 帕金森病神经发生的研究进展[J]. 生命科学研究, 2021, 25(6): 504-508.
WU Zheng, REN Zhi-wei, ZHANG Guo-jun. Research Progress on Neurogenesis in Parkinson’s Disease. Life Science Research, 2021, 25(6): 504-508.