Abstract：Abstract: ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is the core component of autophagic initiation complex and induces cellular autophagy. Canonical autophagy pathway is a process that, through the autophagy-lysosome pathway, which is mediated by a series of autophagy-related proteins, autophagosome can encompass deserted protein and organelles and deliver them to the lysosome. The deserted protein and organelles are finally degraded in the lysosome. Thus the ULK1-induced canonical autophagy is no doubt an important part of cellular “quality control”. Other than the classic function of ULK1 in autophagy, ULK1 can also exert distinct impacts on many life processes, such as apoptosis, pentose phosphate pathway and innate immune response. Moreover, ULK1 is indispensible in glucose and lipid metabolism, red cell formation, endoplasmic reticulumstress response, tumor and nervous system diseases. Considering the importance of ULK1, a general overview is given on ULK1 functions via autophagy and non-autophagy pathways in a variety of human physiological, pathological and disease processes.
引用本文:
谭琳娜, 谭玉勇, 鲁嘉熙, 刘德良. ULK1蛋白激酶通过自噬及非自噬途径介导的生理、病理和疾病研究进展[J]. 生命科学研究, 2019, 23(3): 245-252.
TAN Lin-na, TAN Yu-yong, LU Jia-xi, LIU De-liang. Advances of ULK1 Functions in Human Physiological, Pathological and Disease Processes via Autophagy and Non-autophagy Pathways. Life Science Research, 2019, 23(3): 245-252.
