Abstract:Abstract: Oligopeptide transporter 1 (PepT1), a proton-dependent transporter, is widely distributed in intestinal epithelial cells. PepT1 is responsible for the transport of dipeptides, tripeptides and their analogues, all of which originate from the digestion of proteins. The investigation on PepT1 is of great advantage to improve the bioavailability of drugs, especially those for the treatment of cancer. Here, the crystal structure, prodrugs, substrates, interaction proteins of PepT1, as well as its response to diseases were reviewed.
引用本文:
韩 迪, 韩兴鹏, 郑 健, 李树威, 于 涛. 寡肽转运蛋白(PepT1)的研究进展[J]. 生命科学研究, 2017, 21(6): 542-546.
HAN Di, HAN Xing-peng, ZHENG Jian, LI Shu-wei, YU Tao. Recent Advances of Oligopeptide Transporter 1 (PepT1). Life Science Research, 2017, 21(6): 542-546.