Research Progress of m6A Modification Regulating Autophagy in Male Reproductive Diseases
1. College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China; 2. Tianjin Academy of Agricultural Sciences Animal Husbandry and Veterinary Institute, Tianjin 300384, China
Abstract：N6-Methyladenosine (m6A) modification is methylation of adenosine nucleotides at the N6 position in RNA molecules. It plays a pivotal role in various pathways of RNA metabolism such as mRNA splicing, translation, transportation, and degradation, widely affecting life processes. Autophagy is a natural process in which eukaryotic cells use lysosomes to degrade cytoplasmic proteins and damaged organelles under the regu-lation of autophagy-related genes. Herein, the research progress of m6A modification in regulating autophagy in the occurrence and development of male reproductive diseases was summarized. It aimed to provide refe-rence materials for studing the regulatory mechanisms of male reproduction through autophagy level regula-tion by m6A modification, and offer novel therapeutic strategies for treatment of male reproductive diseases.
