Abstract:Abstract: The cytoophidium is one of the most popular research topics in cell biology. It has guiding significance for clinical diagnosis or treatment because of its biological functions in cell proliferation, metabolism and development. The cytoophidium is a membrane-free organelle polymerized by cytidine triphosphate syn-thetase (CTPS), and its formation process and functions are not the same in different types of cells. It can pro-mote the cancer cell proliferation and lead to disease deterioration. In neural stem cells, cytoophidium over-expression can inhibit the cell proliferation and affect the development of cerebral cortex. And in ovarian follicular cells, the cytoophidium acts as a CTPS repository to increase the cell proliferation and metabolism during oogenesis. Herein, novel findings on the formation process and functions of cytoophidium in different types of cells are summarized for further exploring its potential mechanisms and application value.
引用本文:
李欣玲, 张樱馨, 李进兰, 潘文鑫, 王彦凤, 杨丽蓉, 王 通, 俞晓丽. 细胞蛇的研究进展[J]. 生命科学研究, 2022, 26(1): 54-58.
LI Xin-ling, ZHANG Ying-xin, LI Jin-lan, PAN Wen-xin, WANG Yan-feng, YANG Li-rong, WANG Tong, YU Xiao-li. Advances in Cytoophidium Research. Life Science Research, 2022, 26(1): 54-58.